Tom Waits The Narrator (voice)

Jimmi Simpson Detective David Mills (voice)

Da'Vine Joy Randolph Detective Gail Johnson (voice)

John C. Reilly Donovan Smith (voice)

Bebe Neuwirth Lady Andrea The Giant (voice)

Jason Mantzoukas Tim Snodgrass (voice)

Damon Herriman Street Hustler Boy (voice)

Melissa Villaseñor Sister Mary Margaret (voice)

Kurtwood Smith Carpenter K. Smith (voice)

Tim Heidecker Mayor Kevin De Maximum (voice)

Chris Conrad Detective Nico Onasis (voice)

Hana Mae Lee Christina Smalls (voice)

Alia Shawkat Little Grace (voice)

Julian Barratt The Most Dangerous Man in the World (voice)

Kristen Bell Donella Pecker (voice)

Luis Guzmán Rodrigo Smalls (voice)

Sunita Mani Detective Jaya Mukherjee (voice)

Caleb McLaughlin Trevor Johnson (voice)

Tim Meadows Jeff Thumb (voice)

Terry O'Quinn Captain Krieger (voice)

Dax Shepard Chris Pecker (voice)

Debra Winger Trish McSapphire (voice)